An anti-inflammatory and anti-microbial flavone glycoside from flowers of Cleome viscosa
Department of Chemistry, National Institute of Technology, Tiruchirappalli, Tamil Nadu 620 015, India
Organic and Medicinal Chemistry Letters 2012, 2:19 doi:10.1186/2191-2858-2-19Published: 21 May 2012
Natural products isolated from plant sources have been demonstrated as potential candidates against several ailments. The scientific investigations on the underlying principles of phytotherapy can pave way for the convergence of traditional medicines and modern science and technologies.
Quercetin 3-O-(2′′-acetyl)-glucoside obtained from ethyl acetate fraction of Cleome viscosa is studied against inflammatory of carrageenan-induced rat paw edema ( in vivo) and microbial activity on ( in vitro). The structure of the glycoside is confirmed by means of hydrogen-1 nuclear magnetic resonance spectroscopy, carbon nuclear magnetic resonance spectroscopy, attached proton test, and mass spectrum. The flavonoid glycoside showed significant anti-inflammatory activity of on carrageenan-induced rat paw edema ( in vivo) and anti-microbial activity ( in vitro) on Staphylococcus aureus (gram positive) and Escherichia coli (gram negative). The anti-inflammatory effect of the flavonoid glycoside may be due to the inhibition of prostaglandin synthesis. Selective toxicity with flavonoid glycoside towards the gram-positive bacteria was found on S. aureus.
The present study reveals the anti-inflammatory and antimicrobial activities of an isolated quercetin 3-O-(2′′-acetyl)-glucoside from a natural source ( C. viscosa).