Bismuth nitrate-induced microwave-assisted expeditious synthesis of vanillin from curcumin
Department of Chemistry, The University of Texas-Pan American, 1201 West University Drive, Edinburg, TX 78539, USA
Organic and Medicinal Chemistry Letters 2012, 2:15 doi:10.1186/2191-2858-2-15Published: 20 April 2012
Curcumin and vanillin are the two useful compounds in food and medicine. Bismuth nitrate pentahydrate is an economical and ecofriendly reagent.
Bismuth nitrate pentahydrate impregnated montmorillonite KSF clay and curcumin were subjected to microwave irradiation.
Microwave-induced bismuth nitrate-promoted synthesis of vanillin from curcumin has been accomplished in good yield under solvent-free condition. Twenty-five different reaction conditions have been studied to optimize the process.
The present procedure for the synthesis of vanillin may find useful application in the area of industrial process development.